Pharmacophore Modeling and 3D-QSAR Study of Indole and Isatin Derivatives as Antiamyloidogenic Agents Targeting Alzheimer’s Disease

Thirty-six novel indole-containing compounds, mainly 3-(2-phenylhydrazono) isatins and structurally related 1<i>H</i>-indole-3-carbaldehyde derivatives, were synthesized and assayed as inhibitors of beta amyloid (Aβ) aggregation, a hallmark of pathophysiology of Alzheimer’s disease. The newly synthe...

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Ngā taipitopito rārangi puna kōrero

Ngā kaituhi matua:	Rosa Purgatorio, Nicola Gambacorta, Marco Catto, Modesto de Candia, Leonardo Pisani, Alba Espargaró, Raimon Sabaté, Saverio Cellamare, Orazio Nicolotti, Cosimo D. Altomare
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	MDPI AG 2020-12-01
Rangatū:	Molecules
Ngā marau:	isatin hydrazones indole derivatives antiamyloid agents multitarget-directed ligands 3D-QSAR
Urunga tuihono:	https://www.mdpi.com/1420-3049/25/23/5773
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!