Hepatocytes derived from human induced pluripotent stem cells: Towards establishing an in vitro model for assessing population variability in hepatotoxicity testing

Interindividual differences in response to chemicals have been typically addressed through the use of a 10-fold default “uncertainty” factor. It was only recently that in vitro models emerged to quantitatively assess interindividual variability in the human population for specific chemicals. In the...

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Autors principals:	Xiugong Gao, Rong Li, Kayla Campasino, Miranda R. Yourick, Yang Zhao, Robert L. Sprando, Jeffrey J. Yourick
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2025-01-01
Col·lecció:	Current Research in Toxicology
Matèries:	In vitro model Population variability Ethnicity Hepatotoxicity Hepatocytes Induced pluripotent stem cell
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2666027X25000246
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