Multimodal Proteomics Reveals Dysregulated Secretion and ECM Remodelling in Schizophrenia Patient iPSC-Derived Astrocytes

Astrocytes are increasingly implicated in the pathophysiology of schizophrenia (SCZ), yet how astrocytic dysfunction contributes to disease-relevant neuronal abnormalities remains unclear. Here, we used mass spectrometry–based proteomics to profile lysates (proteome) and secreted proteins (secretome...

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Autors principals:	Wei-Ping Li, Karen E. Laupman, Stephanie D. Beekhuis-Hoekstra, Evangelia Thanou, Remco V. Klaassen, Patrick F. Sullivan, Danielle Posthuma, August B. Smit, Frank Koopmans, Vivi M. Heine
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2026-06-01
Col·lecció:	Cells
Matèries:	schizophrenia astrocytes protein secretion iPSC proteomics
Accés en línia:	https://www.mdpi.com/2073-4409/15/12/1052
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