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Genome-scale metabolic network of human carotid plaque reveals the pivotal role of glutamine/glutamate metabolism in macrophage modulating plaque inflammation and vulnerability

Abstract Background Metabolism is increasingly recognized as a key regulator of the function and phenotype of the primary cellular constituents of the atherosclerotic vascular wall, including endothelial cells, smooth muscle cells, and inflammatory cells. However, a comprehensive analysis of metabol...

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Main Authors: Han Jin, Cheng Zhang, Jan Nagenborg, Peter Juhasz, Adele V. Ruder, Cornelis J. J. M. Sikkink, Barend M. E. Mees, Olivia Waring, Judith C. Sluimer, Dietbert Neumann, Pieter Goossens, Marjo M. P. C. Donners, Adil Mardinoglu, Erik A. L. Biessen
Format: Artigo
Language:Inglês
Published: BMC 2024-07-01
Series:Cardiovascular Diabetology
Subjects:
Plaque rupture
Macrophage
Genome-scale metabolic network
Atherosclerosis
Metabolomics
Online Access:https://doi.org/10.1186/s12933-024-02339-3
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