Noncovalent SUMO-interaction motifs in HIV integrase play important roles in SUMOylation, cofactor binding, and virus replication

Abstract Background HIV integrase (IN) and its cellular cofactors, including lens-epithelium-derived growth factor (LEDGF/p75), Ku70, p300, and Rad52, are subject to small ubiquitin-like modifier (SUMO) modification. In addition to covalent SUMOylation, SUMO paralogs can also noncovalently bind prot...

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Detalhes bibliográficos

Principais autores:	Yingfeng Zheng, Kallesh Danappa Jayappa, Zhujun Ao, Xiangguo Qiu, Ruey-Chyi Su, Xiaojian Yao
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2019-04-01
coleção:	Virology Journal
Assuntos:	Human immunodeficiency virus (HIV) Integrase (IN) SUMOylation SUMO-interacting motifs (SIMs) LEDGF/p75 Protein-protein interaction
Acesso em linha:	http://link.springer.com/article/10.1186/s12985-019-1134-8
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