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Gallic acid attenuates diabetic cardiomyopathy by inhibiting ferroptosis and protecting mitochondria via the TSPO/FTMT pathway

PurposeDiabetic cardiomyopathy (DCM), which is diabetes mellitus-induced cardiomyopathy, significantly elevates the risk of heart failure and sudden cardiac death. No specific treatments for DCM are currently available. Gallic acid (GA) is a polyhydroxyphenolic compound that has been shown to inhibi...

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Principais autores: Chenchao Zou, Huaihan Xu, Fajia Hu, Yuxian Yu, Lanxiang Liu, Xiuqi Wang, Zheyu Zhang, Huaxi Zou, Jichun Liu, Huang Huang, Songqing Lai
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2025-12-01
Serier:Frontiers in Pharmacology
Fag:
phytochemical
diabetic cardiomyopathy
mitochondrial homeostasis
ferroptosis
reactive oxygen species
Online adgang:https://www.frontiersin.org/articles/10.3389/fphar.2025.1661144/full
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