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Stochasticity in the miR-9/Hes1 oscillatory network can account for clonal heterogeneity in the timing of differentiation

Recent studies suggest that cells make stochastic choices with respect to differentiation or division. However, the molecular mechanism underlying such stochasticity is unknown. We previously proposed that the timing of vertebrate neuronal differentiation is regulated by molecular oscillations of a...

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Principais autores: Nick E Phillips, Cerys S Manning, Tom Pettini, Veronica Biga, Elli Marinopoulou, Peter Stanley, James Boyd, James Bagnall, Pawel Paszek, David G Spiller, Michael RH White, Marc Goodfellow, Tobias Galla, Magnus Rattray, Nancy Papalopulu
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2016-10-01
Serier:eLife
Fag:
Hes1
stochasticity
molecular oscillations
miR-9
neural stem cells
single cell heterogeneity
Online adgang:https://elifesciences.org/articles/16118
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