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Optimizing mouse models for mRNA vaccines: addressing dose translation challenges

Abstract The development of mRNA vaccines has significantly advanced global health during the COVID-19 pandemic. However, translating effective vaccine doses from preclinical animal models to human clinical use remains poorly understood. In this study, we evaluated antibody responses and repertoire...

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Autori principali: Zi Wei Chang, Yong Jie Tan, Yiyu Liao, Yun Shan Goh, Syed Ridwan Kabir, Yuqian Wang, Pei Xiang Hor, Chiew Yee Loh, Yuling Huang, Bei Wang, Siti Nazihah Mohd Salleh, Eve Zi Xian Ngoh, COVID-19 Cohort Study Group, NCID Study Group, COVID-19 Clinicians’ Group, Cheng-I Wang, David C. Lye, Barnaby E. Young, Matthew Zirui Tay, Lisa F. P. Ng, Keisuke Ejima, Laurent Renia
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Portfolio 2026-05-01
Serie:Scientific Reports
Soggetti:
Mouse
Human
Dose translation
Antibodies
mRNA vaccine
BNT162b2
Accesso online:https://doi.org/10.1038/s41598-026-47820-z
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