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Matrix-Bound Growth Factors are Released upon Cartilage Compression by an Aggrecan-Dependent Sodium Flux that is Lost in Osteoarthritis

Abstract Articular cartilage is a dense extracellular matrix-rich tissue that degrades following chronic mechanical stress, resulting in osteoarthritis (OA). The tissue has low intrinsic repair especially in aged and osteoarthritic joints. Here, we describe three pro-regenerative factors; fibroblast...

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Autors principals: Stuart J Keppie, Jessica C Mansfield, Xiaodi Tang, Christopher J Philp, Helen K Graham, Patrik Önnerfjord, Alanna Wall, Celia McLean, C Peter Winlove, Michael J Sherratt, Galina E Pavlovskaya, Tonia L Vincent
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2021-01-01
Col·lecció:Function
Matèries:
Growth Factor
Osteoarthritis
Injury
Repair
Cartilage
Extracellular Matrix
Accés en línia:https://journals.physiology.org/doi/10.1093/function/zqab037
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