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SH3BGRL proteins are thioredoxin fold–containing actin filament pointed end capping proteins (TPECs)

Abstract Cellular actin dynamics are tightly regulated by actin-binding proteins with specialized domains. Here, we identify SH3BGRL proteins as modulators of actin dynamics, characterized by their thioredoxin (Trx) fold and the absence of the canonical enzymatic site. The Trx fold is generally asso...

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Principais autores: Robin S. Heiringhoff, Daniel Marke, Ute Curth, Johannes N. Greve
Formato: Artigo
Idioma:Inglês
Publicado: Nature Portfolio 2026-01-01
Series:Scientific Reports
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Acceso en liña:https://doi.org/10.1038/s41598-025-34096-y
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