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H4K20 monomethylation inhibition causes loss of genomic integrity in mouse preimplantation embryos

Maintaining genomic integrity in mammalian early embryos, which are deficient in DNA damage repair, is critical for normal preimplantation and subsequent development. Abnormalities in DNA damage repair in preimplantation embryos can cause not only developmental arrest, but also diseases such as cong...

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Principais autores: Daiki SHIKATA, Takuto YAMAMOTO, Shinnosuke HONDA, Shuntaro IKEDA, Naojiro MINAMI
Format: Artigo
Sprog:Inglês
Udgivet: The Society for Reproduction and Development 2020-05-01
Serier:The Journal of Reproduction and Development
Fag:
genomic integrity
histone h4 lysine 20 monomethylation (h4k20me1)
preimplantation embryo
Online adgang:https://www.jstage.jst.go.jp/article/jrd/66/5/66_2020-036/_pdf/-char/en
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