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Resistance to doxorubicin‐induced proteinuria and proteolytic activation of ENaC in 129S2/SvPas mice

Abstract Doxorubicin treatment of mice represents a convenient model to study the effects of proteinuria on proteolytic processing of the epithelial Na+ channel (ENaC) and urinary Na+ and fluid handling. Prior studies have shown enhanced ENaC γ subunit proteolysis and Na+ and fluid retention in 129S...

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Bibliografische gegevens
Hoofdauteurs: Evan C. Ray, Ivy Liu, Niloofar Momenzadeh, Kennedy Szekely, Allison L. Marciszyn, Tracey Lam, Andrew J. Nickerson, Thomas R. Kleyman
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Wiley 2025-12-01
Reeks:Physiological Reports
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Online toegang:https://doi.org/10.14814/phy2.70667
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