Optimization and In Vitro Characterization of Telmisartan Loaded Sodium Alginate Beads and Its In Vivo Efficacy Investigation in Hypertensive Induced Animal Model

Background: Antihypertensive drug telmisartan (TEL) belongs to BCS class II, which is characterized by low water solubility and, consequently, low oral bioavailability. Gastroretentive systems may overcome the problems associated with low solubility of TEL and incomplete absorption by localizing the...

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Hlavní autoři:	Ubaidulla Uthumansha, Kousalya Prabahar, Dilli Bhai Gajapathy, Mohamed El-Sherbiny, Nehal Elsherbiny, Mona Qushawy
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2023-02-01
Edice:	Pharmaceutics
Témata:	telmisartan (TEL) gastroretentive beads bioavailability central composite design in vitro buoyancy anti-hypertension
On-line přístup:	https://www.mdpi.com/1999-4923/15/2/709
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