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Direct effects of mast cell proteases, tryptase and chymase, on bronchial epithelial integrity proteins and anti-viral responses

Abstract Background Mast cells (MCs) are known to contribute to both acute and chronic inflammation. Bronchial epithelial cells are the first line of defence against pathogens and a deficient anti-viral response has been suggested to play a role in the pathogenesis of asthma exacerbations. However,...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Sangeetha Ramu, Hamid Akbarshahi, Sofia Mogren, Frida Berlin, Samuel Cerps, Mandy Menzel, Morten Hvidtfeldt, Celeste Porsbjerg, Lena Uller, Cecilia K. Andersson
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2021-06-01
Schriftenreihe:BMC Immunology
Schlagworte:
Asthma
Mast cells
Tryptase
Chymase
Human bronchial epithelial cells
Online-Zugang:https://doi.org/10.1186/s12865-021-00424-w
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