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Rare coding variants in CHRNB3 associate with reduced daily cigarette smoking across ancestries

Abstract Rare coding variants that alter protein function and confer beneficial health effects can suggest potential drug targets. CHRNB3 encodes the β3 subunit of nicotinic acetylcholine receptors that bind nicotine and mediate its action in the brain. Here we report an exome-wide association study...

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Hauptverfasser: Veera M. Rajagopal, Andrey Ziyatdinov, Tyler Joseph, Ariane Ayer, Mohsin Ahmed, Joelle Mbatchou, Yuxin Zou, Amelia J. Averitt, Nilanjana Banerjee, Michael Cantor, Jason M. Torres, Esteban Chen, Jennifer Rico Varela, Regeneron Genetics Center, Marcus Jones, John Overton, Olivier Harari, Luca Lotta, Gonçalo Abecasis, Aris Baras, Jaime Berumen, Pablo Kuri-Morales, Jesús Alegre-Díaz, Roberto Tapia-Conyer, Rory Collins, Jonathan R. Emberson, Jonathan Marchini, Giovanni Coppola
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Portfolio 2026-02-01
Schriftenreihe:Nature Communications
Online-Zugang:https://doi.org/10.1038/s41467-026-68825-2
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