Integrative profiling of lactylation reveals prognostic biomarkers and an immunosuppressive niche in acute myeloid leukemia

BackgroundThe overall survival rate of acute myeloid leukemia (AML) remains less than 30%. Metabolic reprogramming of leukemia cells, such as the Warburg effect, enables them to adapt to the microenvironment and thereby develop. Elucidating the landscape of lactate regulation in AML helps clarify th...

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Autori principali:	Zhibo Guo, Wenlei Zhang, Zengliang Gao, Qi Li, Dan Guo, Lijuan Yue, Yutong Liu, Xiaoting Ni, Shengjin Fan, Xin Hai
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2026-03-01
Serie:	Frontiers in Immunology
Soggetti:	acute myeloid leukemia lactylation-related genes leukemic microenvironment machine learning algorithms prognostic marker
Accesso online:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1765979/full
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