Telomere Instability in Lynch Syndrome Families Leads to Some Shorter Telomeres in <i>MSH2+/-</i> Carriers

Lynch syndrome (LS) is an inherited predisposition to early onset of various cancers, caused by mutation in a DNA mismatch repair (MMR) gene. In heterozygous MMR^+/− carriers, somatic mutation, loss or silencing of the wild type allele increases the mutation rate, facilitating the initiati...

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Principais autores:	M. Carmen Garrido-Navas, Frances Tippins, Julian Barwell, Jonathan Hoffman, Veryan Codd, Nicola J. Royle
Formato:	Artigo
Idioma:	Inglês
Publicado:	MDPI AG 2020-10-01
Series:	Life
Assuntos:	telomeres DNA mismatch repair <i>MSH2</i> <i>MLH1</i> Lynch syndrome
Acceso en liña:	https://www.mdpi.com/2075-1729/10/11/265
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