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Reversal of Cancer Multidrug Resistance (MDR) Mediated by ATP-Binding Cassette Transporter G2 (ABCG2) by AZ-628, a RAF Kinase Inhibitor

Overexpression of ABCG2 remains a major impediment to successful cancer treatment, because ABCG2 functions as an efflux pump of chemotherapeutic agents and causes clinical multidrug resistance (MDR). Therefore, it is important to uncover effective modulators to circumvent ABCG2-mediated MDR in cance...

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Principais autores: Jing-Quan Wang, Qiu-Xu Teng, Zi-Ning Lei, Ning Ji, Qingbin Cui, Han Fu, Lizhu Lin, Dong-Hua Yang, Ying-Fang Fan, Zhe-Sheng Chen
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Cell and Developmental Biology
Assuntos:
multidrug resistance
chemotherapy
ABCG2
AZ-628
RAF kinase inhibitor
Acceso en liña:https://www.frontiersin.org/articles/10.3389/fcell.2020.601400/full
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