Neoadjuvant ctDNA-MRD monitoring uncovers occult progression despite radiologic response in locally advanced hypopharyngeal carcinoma: a case report

BackgroundThe assessment of treatment response during neoadjuvant therapy for head and neck squamous cell carcinoma (HNSCC) relies largely on radiographic and endoscopic evaluations, which may fail to detect minimal residual disease (MRD). Circulating tumor DNA (ctDNA)-based MRD monitoring has emerg...

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Detalhes bibliográficos

Principais autores:	Zhaoyang Wang, Lin Gui, Ye Zhang, Shengkai Huang, Shun Wang, Xiwei Zhang, Fa Zhang, Xiaotong Yan, Zongmin Zhang, Shaoyan Liu, Changming An
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-03-01
coleção:	Frontiers in Oncology
Assuntos:	CtDNA hypopharyngeal carcinoma immunochemotherapy MRD neoadjuvant therapy treatment response
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fonc.2026.1748855/full
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