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Glutamylation of centrosomes ensures their function by recruiting microtubule nucleation factors

Abstract Centrosomes are tubulin-based organelles that undergo glutamylation, a post-translational modification that conjugates glutamic acid residues to tubulins. Although centrosomal glutamylation has been known for several decades, how this modification regulates centrosome structure and function...

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Furkejuvvon:
Váldodahkkit: Shi-Rong Hong, Yi-Chien Chuang, Wen-Ting Yang, Chiou-Shian Song, Hung-Wei Yeh, Bing-Huan Wu, I-Hsuan Lin, Po-Chun Chou, Shiau-Chi Chen, Lohitaksh Sharma, Jui-Chen Lu, Rou-Ying Li, Ya-Chu Chang, Kuan-Ju Liao, Hui-Chun Cheng, Won-Jing Wang, Lily Hui-Ching Wang, Yu-Chun Lin
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: Springer Nature 2025-04-01
Ráidu:The EMBO Journal
Fáttát:
Centrosomes
Glutamylation
Microtubules
Primary Cilia
Centriolar satellites
Liŋkkat:https://doi.org/10.1038/s44318-025-00435-y
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