Roles of LRRK2 and its orthologs in protecting against neurodegeneration and neurodevelopmental defects

In humans, variants in the LRRK2 gene are the most prevalent risk factors for Parkinson’s disease (PD). Whereas studies in model organisms have long indicated that the orthologs of the wild-type LRRK proteins protect against neurodegeneration, newer findings indicate that they also protect against n...

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Principais autores:	An Phu Tran Nguyen, Linh Thi Nhat Nguyen, Bailey A. Stokke, Christopher C. Quinn
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2025-04-01
Serija:	Frontiers in Cell and Developmental Biology
Teme:	LRRK2 Parkinson’s disease autism intellectual disability neurodegeneration
Online dostop:	https://www.frontiersin.org/articles/10.3389/fcell.2025.1569733/full
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