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Rare histologic transformation of a CTNNB1 (β-catenin) mutated prostate cancer with aggressive clinical course

Abstract Background Catenin (Cadherin-Associated Protein), Beta 1 (CTNNB1) genomic alterations are rare in prostate cancer (PCa). Gain-of-function mutations lead to overexpression of β-catenin, with consequent hyperactivation of the Wnt/β-catenin signaling pathway, implicated in PCa progression and...

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Hoofdauteurs: Dilara Akhoundova, Stefanie Fischer, Joanna Triscott, Marika Lehner, Phillip Thienger, Sina Maletti, Muriel Jacquet, Dinda S.H. Lubis, Lukas Bubendorf, Wolfram Jochum, Mark A. Rubin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BMC 2024-06-01
Reeks:Diagnostic Pathology
Onderwerpen:
Prostate cancer
Metastatic castration-resistant prostate cancer (mCRPC)
CTNNB1 mutation
Wnt/β-catenin pathway
Histologic transformation
Targeted treatment
Online toegang:https://doi.org/10.1186/s13000-024-01511-3
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