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The Placental NLRP3 Inflammasome and Its Downstream Targets, Caspase-1 and Interleukin-6, Are Increased in Human Fetal Growth Restriction: Implications for Aberrant Inflammation-Induced Trophoblast Dysfunction

Fetal growth restriction (FGR) is commonly associated with placental insufficiency and inflammation. Nonetheless, the role played by inflammasomes in the pathogenesis of FGR is poorly understood. We hypothesised that placental inflammasomes are differentially expressed and contribute to the aberrant...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Irvan Alfian, Amlan Chakraborty, Hannah E. J. Yong, Sheetal Saini, Ricky W. K. Lau, Bill Kalionis, Evdokia Dimitriadis, Nadia Alfaidy, Sharon D. Ricardo, Chrishan S. Samuel, Padma Murthi
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2022-04-01
Schriftenreihe:Cells
Schlagworte:
fetal growth restriction
placental function
inflammasomes
NLRP3
caspase-1
cytokines
Online-Zugang:https://www.mdpi.com/2073-4409/11/9/1413
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