The effect of human factor H on immunogenicity of meningococcal native outer membrane vesicle vaccines with over-expressed factor H binding protein.

The binding of human complement inhibitors to vaccine antigens in vivo could diminish their immunogenicity. A meningococcal ligand for the complement down-regulator, factor H (fH), is fH-binding protein (fHbp), which is specific for human fH. Vaccines containing recombinant fHbp or native outer memb...

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Автори:	Peter T Beernink, Jutamas Shaughnessy, Rolando Pajon, Emily M Braga, Sanjay Ram, Dan M Granoff
Формат:	Artigo
Мова:	Inglês
Опубліковано:	Public Library of Science (PLoS) 2012-01-01
Серія:	PLoS Pathogens
Онлайн доступ:	http://europepmc.org/articles/PMC3349754?pdf=render
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