Inhibition of PTPRS function does not affect the survival or regeneration of dopaminergic neurons but alters synaptic function in the nigrostriatal pathway

Parkinson's Disease (PD) is characterized by midbrain dopaminergic (mDA) neuron degeneration in the ventral midbrain, contributing to debilitating motor symptoms. This study investigated whether Protein Tyrosine Phosphatase Receptor Sigma (PTPRS), a known inhibitor of axonal growth through chondroit...

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Detalhes bibliográficos

Principais autores:	Joshua Peter, Kaejaren C.N. Caldwell, Lucas McClain, Jason Tchieu, Ashley E. Ross, Yu Luo
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2025-09-01
coleção:	Neurobiology of Disease
Assuntos:	PTPRS Dopaminergic neurons Synapses Parkinson's disease
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S0969996125002396
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