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The epiphany derived from T-cell–inflamed profiles: Pan-cancer characterization of CD8A as a biomarker spanning clinical relevance, cancer prognosis, immunosuppressive environment, and treatment responses

CD8A encodes the CD8 alpha chain of αβT cells, which has been proposed as a quantifiable indicator for the assessment of CD8+ cytotoxic T lymphocytes (CTLs) recruitment or activity and a robust biomarker for anti-PD-1/PD-L1 therapy responses. Nonetheless, the lack of research into the role of CD8A i...

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Hlavní autoři: Decao Niu, Yifeng Chen, Hua Mi, Zengnan Mo, Guijian Pang
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2022-08-01
Edice:Frontiers in Genetics
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On-line přístup:https://www.frontiersin.org/articles/10.3389/fgene.2022.974416/full
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