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Chronos: a cell population dynamics model of CRISPR experiments that improves inference of gene fitness effects

Abstract CRISPR loss of function screens are powerful tools to interrogate biology but exhibit a number of biases and artifacts that can confound the results. Here, we introduce Chronos, an algorithm for inferring gene knockout fitness effects based on an explicit model of cell proliferation dynamic...

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Principais autores: Joshua M. Dempster, Isabella Boyle, Francisca Vazquez, David E. Root, Jesse S. Boehm, William C. Hahn, Aviad Tsherniak, James M. McFarland
פורמט: Artigo
שפה:Inglês
יצא לאור: BMC 2021-12-01
סדרה:Genome Biology
גישה מקוונת:https://doi.org/10.1186/s13059-021-02540-7
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