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Protective Roles for Caspase-8 and cFLIP in Adult Homeostasis

Caspase-8 or cellular FLICE-like inhibitor protein (cFLIP) deficiency leads to embryonic lethality in mice due to defects in endothelial tissues. Caspase-8−/− and receptor-interacting protein kinase-3 (RIPK3)−/−, but not cFLIP−/− and RIPK3−/−, double-knockout animals develop normally, indicating tha...

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Principais autores: Ricardo Weinlich, Andrew Oberst, Christopher P. Dillon, Laura J. Janke, Sandra Milasta, John R. Lukens, Diego A. Rodriguez, Prajwal Gurung, Chandra Savage, Thirumala D. Kanneganti, Douglas R. Green
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2013-10-01
Serier:Cell Reports
Online adgang:http://www.sciencedirect.com/science/article/pii/S2211124713005056
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