Stromal interferon-γ signaling and cross-presentation are required to eliminate antigen-loss variants of B cell lymphomas in mice.

To study mechanisms of T cell-mediated rejection of B cell lymphomas, we developed a murine lymphoma model wherein three potential rejection antigens, human c-MYC, chicken ovalbumin (OVA), and GFP are expressed. After transfer into wild-type mice 60-70% of systemically growing lymphomas expressing a...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Armin Gerbitz, Madhusudhanan Sukumar, Florian Helm, Andrea Wilke, Christian Friese, Cornelia Fahrenwaldt, Frank M Lehmann, Christoph Loddenkemper, Thomas Kammertoens, Josef Mautner, Clemens A Schmitt, Thomas Blankenstein, Georg W Bornkamm
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Public Library of Science (PLoS) 2012-01-01
coleção:	PLoS ONE
Acesso em linha:	http://europepmc.org/articles/PMC3316708?pdf=render
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!