Deciphering the Oncogenic Landscape of Hepatocytes Through Integrated Single‐Nucleus and Bulk RNA‐Seq of Hepatocellular Carcinoma

Abstract Hepatocellular carcinoma (HCC) is a major cause of cancer‐related mortality, while the hepatocyte mechanisms driving oncogenesis remains poorly understood. In this study, single‐nucleus RNA sequencing of samples from 22 HCC patients revealed 10 distinct hepatocyte subtypes, including benefi...

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Autori principali:	Huanhou Su, Xuewen Zhou, Guanchuan Lin, Chaochao Luo, Wei Meng, Cui Lv, Yuting Chen, Zebin Wen, Xu Li, Yongzhang Wu, Changtai Xiao, Jian Yang, Jiameng Lu, Xingguang Luo, Yan Chen, Paul KH Tam, Chuanjiang Li, Haitao Sun, Xinghua Pan
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Wiley 2025-04-01
Serie:	Advanced Science
Soggetti:	hepatocellular carcinoma classification hepatocyte subtype metabolic pathway quantile distribution model single‐cell transcriptomics
Accesso online:	https://doi.org/10.1002/advs.202412944
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