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A Mechanistic Pharmacokinetic/Pharmacodynamic Model for Sequence-Dependent Synergy in Pemetrexed–Osimertinib Combinations Against Non-Small Cell Lung Cancer (NSCLC): Translational Insights

<b>Background and Objectives:</b> Combining osimertinib (OSI) with pemetrexed (PEM) can enhance antitumor efficacy; however, the benefit is schedule-dependent. Our previous pharmacodynamic (PD) study showed that concurrent PEM + OSI is limited by OSI-induced G1 arrest, attenuating early PEM cytotoxi...

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Principais autores: Kuan Hu, Yan Lin, Huachun Ji, Tong Yuan, Yu Xia, Jin Yang
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2026-03-01
Serier:Pharmaceutics
Fag:
pemetrexed
osimertinib
synergy effect
schedule-dependent
pharmacokinetic/pharmacodynamic (PK/PD) modeling
Online adgang:https://www.mdpi.com/1999-4923/18/4/408
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