Synthesis and Initial In Vivo Evaluation of [¹¹C]AZ683—A Novel PET Radiotracer for Colony Stimulating Factor 1 Receptor (CSF1R)

Positron emission tomography (PET) imaging of Colony Stimulating Factor 1 Receptor (CSF1R) is a new strategy for quantifying both neuroinflammation and inflammation in the periphery since CSF1R is expressed on microglia and macrophages. AZ683 has high affinity for CSF1R (K<i>_i</i> = 8 nM;...

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Bibliografische Detailangaben

Hauptverfasser:	Sean S. Tanzey, Xia Shao, Jenelle Stauff, Janna Arteaga, Phillip Sherman, Peter J. H. Scott, Andrew V. Mossine
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2018-12-01
Schriftenreihe:	Pharmaceuticals
Schlagworte:	neuroinflammation microglia carbon-11 radiochemistry positron emission tomography
Online-Zugang:	https://www.mdpi.com/1424-8247/11/4/136
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