Chlorotoxin-directed CAR T cell therapy for recurrent glioblastoma: Interim clinical experience demonstrating feasibility and safety

Summary: A challenge in treating glioblastoma (GBM) is its phenotypic heterogeneity between patients and within tumors. Chlorotoxin (CLTX), a peptide from scorpion venom, broadly binds glioma cells through a mechanism involving surface matrix metalloproteinase-2 (MMP-2). We previously developed chim...

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主要な著者:	Michael E. Barish, Maryam Aftabizadeh, Jonathan Hibbard, M. Suzette Blanchard, Julie R. Ostberg, Jamie R. Wagner, Mishika Manchanda, Jinny Paul, Tracy Stiller, Brenda Aguilar, Renate Starr, Leonidas Arvanitis, Julie A. Ressler, Julie Kilpatrick, Yuthana Kong, Dongrui Wang, Stephen J. Forman, Massimo D’Apuzzo, Christine E. Brown, Behnam Badie
フォーマット:	Artigo
言語:	Inglês
出版事項:	Elsevier 2025-08-01
シリーズ:	Cell Reports Medicine
主題:	chlorotoxin chimeric antigen receptor T cells immunotherapy phase 1 clinical trial
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S2666379125003751
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