Targeting the myeloid checkpoint receptor SIRPα potentiates innate and adaptive immune responses to promote anti-tumor activity

Abstract Background Signal regulatory protein α (SIRPα) is a myeloid-lineage inhibitory receptor that restricts innate immunity through engagement of its cell surface ligand CD47. Blockade of the CD47–SIRPα interaction synergizes with tumor-specific antibodies and T-cell checkpoint inhibitors by pro...

وصف كامل

التفاصيل البيبلوغرافية

المؤلفون الرئيسيون:	Tracy C. Kuo, Amy Chen, Ons Harrabi, Jonathan T. Sockolosky, Anli Zhang, Emma Sangalang, Laura V. Doyle, Steven E. Kauder, Danielle Fontaine, Sangeetha Bollini, Bora Han, Yang-Xin Fu, Janet Sim, Jaume Pons, Hong I. Wan
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	BMC 2020-11-01
سلاسل:	Journal of Hematology & Oncology
الموضوعات:	SIRPα CD47 Macrophage Phagocytosis Immunotherapy Innate immune checkpoint
الوصول للمادة أونلاين:	https://doi.org/10.1186/s13045-020-00989-w
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!