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Binary classification of copy number alteration profiles in liquid biopsy with potential clinical impact in advanced NSCLC

Abstract Liquid biopsy has recently emerged as an important tool in clinical practice particularly for lung cancer patients. We retrospectively evaluated cell-free DNA analyses performed at our Institution by next generation sequencing methodology detecting the major classes of genetic alterations....

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Kaydedildi:
Asıl Yazarlar: Valeria Tosello, Angela Grassi, Dominic Rose, Loc Carlo Bao, Elisabetta Zulato, Chiara Dalle Fratte, Maurizio Polano, Paola Del Bianco, Giulia Pasello, Valentina Guarneri, Stefano Indraccolo, Laura Bonanno
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Portfolio 2024-08-01
Seri Bilgileri:Scientific Reports
Konular:
Liquid biopsy
Copy number alterations
Tumor fraction
Machine learning
Immunotherapy
Online Erişim:https://doi.org/10.1038/s41598-024-68229-6
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