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In SARS-CoV-2 delta variants, Spike-P681R and D950N promote membrane fusion, Spike-P681R enhances spike cleavage, but neither substitution affects pathogenicity in hamstersResearch in context

Summary: Background: The SARS-CoV-2 delta (B.1.617.2 lineage) variant was first identified at the end of 2020 and possessed two unique amino acid substitutions in its spike protein: S-P681R, at the S1/S2 cleavage site, and S-D950N, in the HR1 of the S2 subunit. However, the roles of these substitut...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Yuri Furusawa, Maki Kiso, Shun Iida, Ryuta Uraki, Yuichiro Hirata, Masaki Imai, Tadaki Suzuki, Seiya Yamayoshi, Yoshihiro Kawaoka
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2023-05-01
Schriftenreihe:EBioMedicine
Schlagworte:
SARS-CoV-2
COVID-19
Reverse genetics
Hamster
Online-Zugang:http://www.sciencedirect.com/science/article/pii/S2352396423001263
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