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HIV-1 subtype C Nef-mediated SERINC5 down-regulation significantly contributes to overall Nef activity

Abstract Background Nef performs multiple cellular activities that enhance HIV-1 pathogenesis. The role of Nef-mediated down-regulation of the host restriction factor SERINC5 in HIV-1 pathogenesis is not well-defined. We aimed to investigate if SERINC5 down-regulation activity contributes to HIV-1 s...

Whakaahuatanga katoa

I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Delon Naicker, Nelson Sonela, Steven W. Jin, Takalani Mulaudzi, Doty Ojwach, Tarylee Reddy, Mark A. Brockman, Zabrina L. Brumme, Thumbi Ndung’u, Jaclyn K. Mann
Hōputu: Artigo
Reo:Inglês
I whakaputaina: BMC 2023-03-01
Rangatū:Retrovirology
Ngā marau:
Urunga tuihono:https://doi.org/10.1186/s12977-023-00618-7
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