Antibody-gamma/delta T cell receptors targeting GPC2 regress neuroblastoma with low antigen density

Summary: Chimeric antigen receptor (CAR) T cells have shown promise in hematological cancers but face challenges in solid tumors, partly due to heterogeneous antigen density. Glypican-2 (GPC2) is an oncofetal antigen highly expressed in neuroblastoma and under evaluation in phase 1 clinical trials....

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Hlavní autoři:	Alex Quan, Mingyu Huo, Dan Li, Laura E. Hutchins, Constanza Rodriguez, Jangsuk Oh, Hsi-En Tsao, Madeline Spetz, Elijah Edmondson, Dana Ashworth, Rui Zheng, Jing Zhou, Jinyun Chen, Jingbao Liu, Guangyan Xiong, Hongbing Zhang, Cheng Liu, Rosa Nguyen, Nan Li, Mitchell Ho
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2025-10-01
Edice:	Cell Reports Medicine
Témata:	neuroblastoma glypican-2 GPC2 monoclonal antibody antibody humanization gamma/delta TCR
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2666379125004513
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