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Diosmin-Hesperidin fixed-dose combination ameliorates cisplatin-induced hepotorenal toxicities in wistar rats: Involvements of antioxidant and anti-inflammatory mechanisms

The chemotherapeutic agent, cisplatin (CIS), is limited by significant hepatorenal toxicity. This study evaluated the protective efficacy of a micronized diosmin (90 %) and hesperidin (10 %) combination (DH) against this toxicity in young adult male Wistar rats. In a dose-response study, rats were o...

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Principais autores: Adejuwon A. Adeneye, Favor O. Ogunole, Quadri Remi-Lawal, Abdulfatai Ojewale, Ikechuckwu I. Okoye
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2025-11-01
Serier:Phytomedicine Plus
Fag:
Wistar rats
Diosmin-hesperidin fixed-dose combination
Cisplatin
Off-target hepatorenal toxicity
Online adgang:http://www.sciencedirect.com/science/article/pii/S2667031325001770
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