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A quadral biosignature of IFN-γ, IL-2, IL-12 and IP-10 increases the diagnostic potential for latent tuberculosis among diabetic patients in Uganda

Abstract Background Type 2 diabetes mellitus (DM) increases both the risk of acquiring latent tuberculosis (TB) infection (LTBI) and progression to active TB. The immunological mechanisms underlying the increased susceptibility remain poorly understood. This study aimed to elucidate the impact of DM...

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Principais autores: Phillip Ssekamatte, Diana Sitenda, Rose Nabatanzi, Marjorie Nakibuule, Davis Kibirige, Andrew Peter Kyazze, David Patrick Kateete, Bernard Ssentalo Bagaya, Obondo James Sande, Reinout van Crevel, Stephen Cose, Irene Andia Biraro
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2025-11-01
Serier:BMC Immunology
Fag:
Latent tuberculosis infection
Diabetes mellitus
Mycobacterium tuberculosis
Cytokines
Chemokines
Biomarkers
Online adgang:https://doi.org/10.1186/s12865-025-00771-y
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