Development and Application of a Mechanistic Population Modeling Approach to Describe Abemaciclib Pharmacokinetics
Abemaciclib is an oral anticancer drug that inhibits cyclin dependent kinases 4 and 6 and is metabolized by cytochrome P450 3A in the intestines and liver to active metabolites. The objectives were (1) to develop a mechanistic model to characterize the pharmacokinetics (PK) of the active moieties an...
Gardado en:
| Principais autores: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Wiley
2020-09-01
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| Series: | CPT: Pharmacometrics & Systems Pharmacology |
| Acceso en liña: | https://doi.org/10.1002/psp4.12544 |
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