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Immunogenicity and protective efficacy on non-adjuvanted CD40-targeting SARS-CoV-2 vaccines in non-human primatesResearch in context

Summary: Background: The emergence of antigenically distinct SARS-CoV-2 variants increases the risk of immune escape and requires continually updated vaccines. In addition, short-lived specific immunity is a limitation faced by current COVID-19 mRNA vaccines against Sarbecoviruses. This underscores...

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Asıl Yazarlar: Romain Marlin, Mireille Centlivre, Laetitia Bossevot, Anne-Sophie Gallouët, Marie Alexandre, Delphine Planas, Mariangela Cavarelli, Isabelle Staropoli, Wesley Gros, Mathieu Surenaud, Craig Fenwick, Sylvain Cardinaud, Mathilde Galhaut, Sandra Zurawski, Victor Magneron, Loïc Pintore, Cécile Hérate, Marie-Anne Rameix Welti, Paul Mazet, Vanessa Contreras, Francis Relouzat, Nathalie Dereuddre-Bosquet, Giuseppe Pantaleo, Rodolphe Thiébaut, Mélanie Prague, Olivier Schwartz, Gerard Zurawski, Véronique Godot, Roger Le Grand, Yves Lévy
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Elsevier 2026-07-01
Seri Bilgileri:EBioMedicine
Konular:
Preclinical study
Immunogenicity
SARS-CoV-2 vaccine candidate
Non-human primate
Dendritic cell targeting vaccine
CD40
Online Erişim:http://www.sciencedirect.com/science/article/pii/S2352396426002446
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