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Chronic Caffeine Treatment Protects Against α-Synucleinopathy by Reestablishing Autophagy Activity in the Mouse Striatum

Despite converging epidemiological evidence for the inverse relationship of regular caffeine consumption and risk of developing Parkinson's disease (PD) with animal studies demonstrating protective effect of caffeine in various neurotoxin models of PD, whether caffeine can protect against mutant α-s...

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Principais autores: Yanan Luan, Xiangpeng Ren, Wu Zheng, Zhenhai Zeng, Yingzi Guo, Zhidong Hou, Wei Guo, Xingjun Chen, Fei Li, Jiang-Fan Chen
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018-05-01
Serier:Frontiers in Neuroscience
Fag:
α-synuclein
caffeine
autophagy
macroautophagy
α-synucleinopathy
Parkinson's disease
Online adgang:http://journal.frontiersin.org/article/10.3389/fnins.2018.00301/full
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