Introduction of new quinolone-2-thio-acetamide-propane hydrazide-benzimidazole derivatives as new α-glucosidase and α-amylase inhibitors

Abstract In the present work, new quinolone-2-thio-acetamide-propane hydrazide-benzimidazole derivatives 12a-o were assigned as potent anti-diabetic agents that targeting α-glucosidase and α-amylase as two important targets in treatment of type 2 diabetes. General scaffold of these compounds was des...

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Detalhes bibliográficos

Principais autores:	Parisa Nikfar, Somaye Karimian, Sajedeh Safapoor, Milad Noori, Navid Dastyafteh, Seyedeh Niloufar Ghafouri, Maryam Mohammadi-Khanaposhtani, Bagher Larijani, Parham Taslimi, Mohammad Mahdavi
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2025-08-01
coleção:	Scientific Reports
Assuntos:	Quinolone-2-thio-acetamide Propane hydrazide Benzimidazole Α-Glucosidase Α-Amylase
Acesso em linha:	https://doi.org/10.1038/s41598-025-16661-7
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