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In Silico Analyses of the Role of Codon Usage at the Hemagglutinin Cleavage Site in Highly Pathogenic Avian Influenza Genesis

A vast diversity of 16 influenza hemagglutinin (HA) subtypes are found in birds. Interestingly, viruses from only two subtypes, H5 and H7, have so far evolved into highly pathogenic avian influenza viruses (HPAIVs) following insertions or substitutions at the HA cleavage site by the viral polymerase...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Mathis Funk, Anja C. M. de Bruin, Monique I. Spronken, Alexander P. Gultyaev, Mathilde Richard
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2022-06-01
Schriftenreihe:Viruses
Schlagworte:
highly pathogenic avian influenza viruses
low-pathogenic avian influenza viruses
multi-basic cleavage site
evolution
RNA-dependent RNA polymerase
insertions
Online-Zugang:https://www.mdpi.com/1999-4915/14/7/1352
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