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Rapid Hypermutation B Cell Trajectory Recruits Previously Primed B Cells Upon Third SARS-Cov-2 mRNA Vaccination

The COVID-19 pandemic shows that vaccination strategies building on an ancestral viral strain need to be optimized for the control of potentially emerging viral variants. Therefore, aiming at strong B cell somatic hypermutation to increase antibody affinity to the ancestral strain - not only at high...

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Principais autores: Lisa Paschold, Bianca Klee, Cornelia Gottschick, Edith Willscher, Sophie Diexer, Christoph Schultheiß, Donjete Simnica, Daniel Sedding, Matthias Girndt, Michael Gekle, Rafael Mikolajczyk, Mascha Binder
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2022-05-01
Serier:Frontiers in Immunology
Fag:
SARS-CoV-2
COVID-19
delta
B cell maturation
omicron variant
booster vaccination
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2022.876306/full
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