All-trans retinoic acid (ATRA) regulates key genes in the RARG-TOP2B pathway and reduces anthracycline-induced cardiotoxicity.

The effectiveness of anthracycline chemotherapeutics (e.g., doxorubicin) is limited by anthracycline-induced cardiotoxicity (ACT). A nonsynonymous variant (S427L) in the retinoic acid receptor-γ (RARG) gene has been associated with ACT. This variant causes reduced RARG activity, which is hypothesize...

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Auteurs principaux:	Jafar S Hasbullah, Erika N Scott, Amit P Bhavsar, Erandika P Gunaretnam, Fudan Miao, Hesham Soliman, Bruce C Carleton, Colin J D Ross
Format:	Artigo
Langue:	Inglês
Publié:	Public Library of Science (PLoS) 2022-01-01
Collection:	PLoS ONE
Accès en ligne:	https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0276541&type=printable
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