Fine tuning a logical model of cancer cells to predict drug synergies: combining manual curation and automated parameterization

Treatment with combinations of drugs carries great promise for personalized therapy for a variety of diseases. We have previously shown that synergistic combinations of cancer signaling inhibitors can be identified based on a logical framework, by manual model definition. We now demonstrate how auto...

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Detalhes bibliográficos

Principais autores:	Åsmund Flobak, John Zobolas, Miguel Vazquez, Tonje S. Steigedal, Liv Thommesen, Asle Grislingås, Barbara Niederdorfer, Evelina Folkesson, Martin Kuiper
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2023-11-01
Colecção:	Frontiers in Systems Biology
Assuntos:	logical modeling cancer synergy genetic algorithm & optimization technique xenograft analysis cell line
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fsysb.2023.1252961/full
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