Molecular interactions between a diphenyl scaffold and PED/PEA15: Implications for type II diabetes therapeutics targeting PED/PEA15 – Phospholipase D1 interaction

In a recent study, we have identified BPH03 as a promising scaffold for the development of compounds aimed at modulating the interaction between PED/PEA15 (Phosphoprotein Enriched in Diabetes/Phosphoprotein Enriched in Astrocytes 15) and PLD1 (phospholipase D1), with potential applications in type I...

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Principais autores:	Ivan Mercurio, Gianluca D’Abrosca, Maria della Valle, Gaetano Malgieri, Roberto Fattorusso, Carla Isernia, Luigi Russo, Sonia Di Gaetano, Emilia Maria Pedone, Luciano Pirone, Annarita Del Gatto, Laura Zaccaro, Domenico Alberga, Michele Saviano, Giuseppe Felice Mangiatordi
Format:	Artigo
Jezik:	Inglês
Izdano:	American Association for the Advancement of Science (AAAS) 2024-12-01
Serija:	Computational and Structural Biotechnology Journal
Teme:	Phosphoprotein Enriched in Diabetes/Phosphoprotein Enriched in Astrocytes 15 Type II diabetes Molecular Dynamics Cavity mapping Nuclear Magnetic Resonance
Online dostop:	http://www.sciencedirect.com/science/article/pii/S2001037024001466
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