Omega-3 fatty acid DHA induces ferroptosis in colorectal cancer patient-derived organoids and drug-tolerant cells

Abstract Several epidemiological and preclinical studies suggest that omega-3 (n-3) polyunsaturated fatty acids (PUFAs) exert anticancer activity at multiple stages of colorectal cancer (CRC) progression. However, inconsistent clinical evidence and the lack of a clearly defined molecular mechanism u...

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Главные авторы:	Laura di Blasio, Marianela Vara-Messler, Barbara Peracino, Elena Masti, Vanesa Cepas-López, Livio Trusolino, Alberto Puliafito, Andrea Bertotti, Valentina Monica, Luca Primo
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Nature Publishing Group 2026-04-01
Серии:	Cell Death and Disease
Online-ссылка:	https://doi.org/10.1038/s41419-026-08744-8
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